Combatting chemoresistance in GBM

Combatting chemoresistance in GBM
By using a combinational therapeutic strategy, a research team have created a promising approach to combat chemoresistance in GBM. Glioblastoma often resists front-line chemotherapies, including temozolomide, a drug that damages DNA and triggers tumour cell death. Nearly half of glioblastoma patients resist the treatment by producing a DNA-repairing enzyme, MGMT, but until recently it wasn’t clear why temozolomide wasn’t working for patients who lacked the MGMT enzyme. Using glioblast...

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